BRK1

2022-11-15 | Categories genes  | Tags meiosis  sterile 

• Information
  • Symbol: BRK1
  • MSU: LOC_Os07g32480
  • RAPdb: Os07g0508500
• PSP score
  • LOC_Os07g32480.1: 0.0241
• PLAAC score
  • LOC_Os07g32480.1: 0
• pLDDT score
  • 83.58
• Protein Structure from AlphaFold and UniProt
  • 
• Publication
  • BRK1, a Bub1-related kinase, is essential for generating proper tension between homologous kinetochores at metaphase I of rice meiosis, 2012, Plant Cell.
• Genbank accession number
  • JQ990990
  • AK064439
  • JQ990990
  • AK064439
• Key message
  • Although the homologs can faithfully separate from each other at the end of meiosis I, the uncorrected merotelic attachment of paired sister kinetochores at the early stage of metaphase I in brk1 reduces the tension across homologous kinetochores, causes the metaphase I spindle to be aberrantly shaped, and subsequently affects the synchronicity of homolog separation at the onset of anaphase I
  • BRK1, a Bub1-related kinase, is essential for generating proper tension between homologous kinetochores at metaphase I of rice meiosis
  • The brk1 mutants are sterile due to the precocious separation of sister chromatids at the onset of anaphase I
• Connection

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