CFL1

2022-11-15 | Categories genes  | Tags cuticle  transcription factor  leaf 

• Information
  • Symbol: CFL1
  • MSU: LOC_Os02g31140
  • RAPdb: Os02g0516400
• PSP score
  • LOC_Os02g31140.1: 0.995
• PLAAC score
  • LOC_Os02g31140.1: 0
• pLDDT score
  • 53.06
• Protein Structure from AlphaFold and UniProt
  • 
• Publication
  • CFL1, a WW domain protein, regulates cuticle development by modulating the function of HDG1, a class IV homeodomain transcription factor, in rice and Arabidopsis, 2011, Plant Cell.
• Genbank accession number
  • Q67UM8
• Key message
  • We overexpressed both rice and Arabidopsis CFL1 in Arabidopsis thaliana; these transgenic plants showed severely impaired cuticle development, similar to that in cfl1 rice
  • Reduced expression of At CFL1 resulted in reinforcement of cuticle structure
  • Suppression of HDG1 function resulted in similar defective cuticle phenotypes in wild-type Arabidopsis but much alleviated phenotypes in At cfl1-1 mutants
  • The expression of two cuticle development-associated genes, BDG and FDH, was downregulated in At CFL1 overexpressor and HDG1 suppression plants
  • Our results suggest that rice and Arabidopsis CFL1 negatively regulate cuticle development by affecting the function of HDG1, which regulates the downstream genes BDG and FDH
  • CFL1, a WW domain protein, regulates cuticle development by modulating the function of HDG1, a class IV homeodomain transcription factor, in rice and Arabidopsis
  • Biochemical evidence showed that At CFL1 interacts with HDG1, a class IV homeodomain-leucine zipper transcription factor
  • We identified a rice (Oryza sativa) dominant curly leaf mutant, curly flag leaf1 (cfl1), and cloned CFL1, which encodes a WW domain protein
• Connection

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