- Information
- Symbol: LARGE1,OML4,EHD6
- MSU: LOC_Os02g31290
- RAPdb: Os02g0517531
- PSP score
- LOC_Os02g31290.1: 0.9932
- LOC_Os02g31290.2: 0.9932
- PLAAC score
- LOC_Os02g31290.1: 7.077
- LOC_Os02g31290.2: 7.077
- pLDDT score
- LOC_Os02g31290.1: 52.41
- reported condensate
Cui et al., 2024, Mol Plant, 17:935-954
- Protein Structure from AlphaFold and UniProt
- MolPhase score
- LOC_Os02g31290.1: 0.99984896
- LOC_Os02g31290.2: 0.99984896
- MolPhase Result
- Publication
-
Genbank accession number
- Key message
- Here we report that the MEI2-LIKE PROTEIN 4 (OML4) encoded by the LARGE1 gene is phosphorylated by the GLYCOGEN SYNTHASE KINASE 2 (GSK2) and negatively controls grain size and weight in rice
- We found that EHD6 can physically interact with YTH07. We showed that their interaction enhances the binding of the m6A-modified OsCOL4 mRNA and trigers relocation of a portion of YTH07 from the cytoplasm into RNP granuels through phase-separated condensates.
- Connection
- GSK2~OsGSK2~OsSK22, LARGE1~OML4~EHD6, Control of Grain Size and Weight by the GSK2-LARGE1/OML4 Pathway in Rice., Here we report that the MEI2-LIKE PROTEIN 4 (OML4) encoded by the LARGE1 gene is phosphorylated by the GLYCOGEN SYNTHASE KINASE 2 (GSK2) and negatively controls grain size and weight in rice.
- YTH07, LARGE1~OML4~EHD6, The RNA binding protein EHD6 recruits the m6A reader YTH07 and sequesters OsCOL4 mRNA into phase-separated ribonucleoprotein condensates to promote rice flowering., we found that EHD6 forms RNP granules together with YTH07 and sequesters OsCOL4 mRNA, thus promoting flowering through the Ehd1 pathway.
