LRD6-6,LMR

2022-11-15 | Categories genes  | Tags ATPase  defense response  cell death  PCD  lesion mimic  immunity  R protein  vesicular  vesicular trafficking 

• Information
  • Symbol: LRD6-6,LMR
  • MSU: LOC_Os06g03940
  • RAPdb: Os06g0130000
• PSP score
  • LOC_Os06g03940.1: 0.5422
• PLAAC score
  • LOC_Os06g03940.1: 0
• pLDDT score
  • 78.52
• Protein Structure from AlphaFold and UniProt
  • 
• Publication
  • The rice Oryza sativa L. LESION MIMIC RESEMBLING, which encodes an AAA-type ATPase, is implicated in defense response., 2014, Mol Genet Genomics.
  • The Multivesicular Bodies MVBs-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice., 2016, PLoS Genet.
• Genbank accession number
  • AK070084
• Key message
  • The rice (Oryza sativa L.) LESION MIMIC RESEMBLING, which encodes an AAA-type ATPase, is implicated in defense response.
  • The pathogenesis-related (PR) genes PBZ1 and PR1 were induced in lmr, which also showed enhanced resistance to rice blast (Magnaporthe oryzae) and bacterial blight (Xanthomonas oryzae pv. oryzae), suggesting LMR is a negative regulator of cell death in rice.
  • The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice.
  • Here we report the identification and characterization of a MVBs-localized AAA ATPase LRD6-6 in rice
  • The ATPase activity and homo-dimerization of LRD6-6 is essential for its regulation on plant immunity and cell death
  • Collectively, our study shows that the AAA ATPase LRD6-6 inhibits plant immunity and cell death most likely through modulating MVBs-mediated vesicular trafficking in rice
  • Disruption of LRD6-6 leads to enhanced immunity and cell death in rice
  • The LRD6-6 protein co-localizes with the MVBs marker protein RabF1/ARA6 and interacts with ESCRT-III components OsSNF7 and OsVPS2
  • Further analysis reveals that LRD6-6 is required for MVBs-mediated vesicular trafficking and inhibits the biosynthesis of antimicrobial compounds
• Connection
  • LRD6-6~LMR, MEL1, Histone H3 modifications are widely reprogrammed during male meiosis I in rice dependently on MEL1 Argonaute protein., LMR occurred dependently on a rice Argonaute protein, MEIOSIS ARRESTED AT LEPTOTENE1 (MEL1), which is specifically expressed in germ cells prior to meiosis, because LMR was depleted severely in mel1 mutant anthers
  • LRD6-6~LMR, MEL1, Histone H3 modifications are widely reprogrammed during male meiosis I in rice dependently on MEL1 Argonaute protein., Interestingly, opposed to the LMR loss in most chromosomal regions, aberrant meiotic protein loading and hyper H3K9me2 accumulation emerged on the nucleolar organizing region in the mel1 PMCs
  • LRD6-6~LMR, MEL1, Histone H3 modifications are widely reprogrammed during male meiosis I in rice dependently on MEL1 Argonaute protein., These results suggest that MEL1 plays important roles in epigenetic LMR to promote faithful homologous recombination and synapsis in rice meiosis

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