- Information
- Symbol: OsHrd3
- MSU: LOC_Os03g15350
- RAPdb: Os03g0259300
- PSP score
- LOC_Os03g15350.1: 0.4365
- PLAAC score
- LOC_Os03g15350.1: 0
- pLDDT score
- 84.6
- Protein Structure from AlphaFold and UniProt
- MolPhase score
- LOC_Os03g15350.1: 0.99600607
- MolPhase Result
- Publication
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Genbank accession number
- Key message
- Since Hrd3/SEL1L recognizes unfolded proteins in yeast and mammalian protein quality control systems, the role of OsHrd3 in protein quality control in rice endosperm was investigated
- Co-immunoprecipitation experiments demonstrated that OsHrd3 interacts with components of the Hrd1 ubiquitin ligase complex such as OsOS-9 and OsHrd1 in rice protoplasts
- OsHrd3 is necessary for maintaining the quality of endoplasmic reticulum-derived protein bodies in rice endosperm.
- Endosperm-specific suppression of OsHrd3 in transgenic rice reduced the levels of polyubiquitinated proteins and resulted in unfolded protein responses (UPRs) in the endosperm, suggesting that OsHrd3-mediated polyubiquitination plays an important role in ER quality control
- Connection
- OsHrd1, OsHrd3, OsHrd3 is necessary for maintaining the quality of endoplasmic reticulum-derived protein bodies in rice endosperm., Co-immunoprecipitation experiments demonstrated that OsHrd3 interacts with components of the Hrd1 ubiquitin ligase complex such as OsOS-9 and OsHrd1 in rice protoplasts
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