- Information
- Symbol: OsMPK6,OsMPK4
- MSU: LOC_Os10g38950
- RAPdb: Os10g0533600
- PSP score
- LOC_Os10g38950.1: 0.0272
- PLAAC score
- LOC_Os10g38950.1: 0
- pLDDT score
- 88.68
- Protein Structure from AlphaFold and UniProt
- Publication
- Mitogen-activated protein kinase OsMPK6 negatively regulates rice disease resistance to bacterial pathogens, 2007, Planta.
- OsWRKY30 is activated by MAP kinases to confer drought tolerance in rice, 2012, Plant Mol Biol.
- Biochemical identification of the OsMKK6-OsMPK3 signalling pathway for chilling stress tolerance in rice, 2012, Biochem J.
- Opposite functions of a rice mitogen-activated protein kinase during the process of resistance against Xanthomonas oryzae, 2010, Plant J.
- Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection, 2006, Mol Plant Microbe Interact.
- A calmodulin-binding mitogen-activated protein kinase phosphatase is induced by wounding and regulates the activities of stress-related mitogen-activated protein kinases in rice, 2007, Plant Cell Physiol.
- A cold-induced thioredoxin h of rice, OsTrx23, negatively regulates kinase activities of OsMPK3 and OsMPK6 in vitro, 2009, FEBS Lett.
- A redox-sensitive cysteine residue regulates the kinase activities of OsMPK3 and OsMPK6 in vitro., 2014, Plant Sci.
- Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6., 2015, PLoS Pathog.
- OsMPK6 plays a critical role in cell differentiation during early embryogenesis in Oryza sativa., 2016, J Exp Bot.
- Discovery of rice essential genes by characterizing CRISPR-edited mutation of closely related rice MAP kinase genes., 2016, Plant J.
- WRKY45 phosphorylation at threonine 266 acts negatively on WRKY45-dependent blast resistance in rice., 2017, Plant Signal Behav.
- Genbank accession number
- Key message
- An MBP (myelin basic protein) kinase assay of the immunoprecipitation complex indicated that OsMPK3 and OsMPK6 were activated in response to a moderately low temperature (12 degrees C), but not a severely low temperature (4 degrees C) in rice seedlings
- Activation of OsMPK6 resulted in the formation of lesion mimics and local resistance to Xoo, accompanied by the accumulation of salicylic acid (SA) and jasmonic acid (JA), and the induced expression of SA- and JA-signaling genes
- These results suggest that OsMPK6 functions as a repressor to regulate rice defense responses upon bacterial invasion
- Nuclear localization of OsMPK6 was essential for local resistance, suggesting that modulating the expression of defense-responsive genes through transcription regulators may be the primary mechanism of OsMPK6-mediated local resistance
- Here we report that OsMPK6 is an important regulator in rice disease resistance
- Mitogen-activated protein kinase OsMPK6 negatively regulates rice disease resistance to bacterial pathogens
- The knock-out of OsMPK6 resulted in enhanced Xoo resistance, increased accumulation of SA and enhanced resistance to X
- Xoo infection induced the expression of PR1a, the marker gene of systemic acquired resistance (SAR), in systemic health tissues of OsMPK6-knock-out plants
- Here, immunoprecipitated OsMPK3 and OsMPK6 were initially activated in 15min, and this activation transiently increased in rice seedlings under H2O2 stress
- A redox-sensitive cysteine residue regulates the kinase activities of OsMPK3 and OsMPK6 in vitro.
- An ABA treatment dephosphorylated/inactivated OsMPK6 via protein tyrosine phosphatases, OsPTP1/2, leading to the impaired activation of WRKY45 and a reduction in Magnaporthe oryzae resistance, even after BTH treatment
- WRKY45 is a central regulator of disease resistance mediated by salicylic acid signaling in rice and its activation involves phosphorylation by OsMPK6
- Connection
- OsMPK14, OsMPK6~OsMPK4, OsWRKY30 is activated by MAP kinases to confer drought tolerance in rice, Here, we have shown that OsWRKY30 interacted with OsMPK3, OsMPK4, OsMPK7, OsMPK14, OsMPK20-4, and OsMPK20-5, and could be phosphorylated by OsMPK3, OsMPK7, and OsMPK14
- OsMPK6~OsMPK4, OsMPK7, OsWRKY30 is activated by MAP kinases to confer drought tolerance in rice, Here, we have shown that OsWRKY30 interacted with OsMPK3, OsMPK4, OsMPK7, OsMPK14, OsMPK20-4, and OsMPK20-5, and could be phosphorylated by OsMPK3, OsMPK7, and OsMPK14
- OsMPK6~OsMPK4, OsWRKY30, OsWRKY30 is activated by MAP kinases to confer drought tolerance in rice, Here, we have shown that OsWRKY30 interacted with OsMPK3, OsMPK4, OsMPK7, OsMPK14, OsMPK20-4, and OsMPK20-5, and could be phosphorylated by OsMPK3, OsMPK7, and OsMPK14
- OsMEK1~OsMKK6, OsMPK6~OsMPK4, Biochemical identification of the OsMKK6-OsMPK3 signalling pathway for chilling stress tolerance in rice, In the present study, we performed yeast two-hybrid screening to identify partner MAPKs for OsMKK (Oryza sativa MAPK kinase) 6, a rice MAPK kinase, and revealed specific interactions of OsMKK6 with OsMPK3 and OsMPK6
- OsMEK1~OsMKK6, OsMPK6~OsMPK4, Biochemical identification of the OsMKK6-OsMPK3 signalling pathway for chilling stress tolerance in rice, OsMPK3 and OsMPK6 each co-immunoprecipitated OsMKK6, and both were directly phosphorylated by OsMKK6 in vitro
- OsMEK1~OsMKK6, OsMPK6~OsMPK4, Biochemical identification of the OsMKK6-OsMPK3 signalling pathway for chilling stress tolerance in rice, A constitutively active form of OsMKK6, OsMKK6DD, showed elevated phosphorylation activity against OsMPK3 and OsMPK6 in vitro
- OsMEK1~OsMKK6, OsMPK6~OsMPK4, Biochemical identification of the OsMKK6-OsMPK3 signalling pathway for chilling stress tolerance in rice, OsMPK3, but not OsMPK6, was constitutively activated in transgenic plants overexpressing OsMKK6DD, indicating that OsMPK3 is an in vivo target of OsMKK6
- OsMPK6~OsMPK4, OsPR1a~OsSCP, Opposite functions of a rice mitogen-activated protein kinase during the process of resistance against Xanthomonas oryzae, Xoo infection induced the expression of PR1a, the marker gene of systemic acquired resistance (SAR), in systemic health tissues of OsMPK6-knock-out plants
- OsMKP1, OsMPK6~OsMPK4, A calmodulin-binding mitogen-activated protein kinase phosphatase is induced by wounding and regulates the activities of stress-related mitogen-activated protein kinases in rice, Activities of two stress-responsive MAPKs, OsMPK3 and OsMPK6, in osmkp1 were higher than those in the wild type both before and after wounding
- OsMPK6~OsMPK4, OsTrx23~OsTRXh1, A cold-induced thioredoxin h of rice, OsTrx23, negatively regulates kinase activities of OsMPK3 and OsMPK6 in vitro, Here, we report that a major and cold-induced thioredoxin h of rice, OsTrx23, has an inhibitory activity on stress-activated mitogen-activated protein kinases (MAPKs), OsMPK3 and OsMPK6 in vitro
- OsMPK6~OsMPK4, OsTrx23~OsTRXh1, A cold-induced thioredoxin h of rice, OsTrx23, negatively regulates kinase activities of OsMPK3 and OsMPK6 in vitro, A cold-induced thioredoxin h of rice, OsTrx23, negatively regulates kinase activities of OsMPK3 and OsMPK6 in vitro
- OsMPK6~OsMPK4, SIT1, The Receptor-Like Kinase SIT1 Mediates Salt Sensitivity by Activating MAPK3/6 and Regulating Ethylene Homeostasis in Rice, SIT1 phosphorylates MPK3 and 6, and their activation by salt requires SIT1
- OsMPK6~OsMPK4, OsMSRMK2~OsMAP1~OsMPK5~OsMAPK2~OsMAPK5~OsBIMK1~OsMPK3, A redox-sensitive cysteine residue regulates the kinase activities of OsMPK3 and OsMPK6 in vitro., A redox-sensitive cysteine residue regulates the kinase activities of OsMPK3 and OsMPK6 in vitro.
- OsMPK6~OsMPK4, OsMSRMK2~OsMAP1~OsMPK5~OsMAPK2~OsMAPK5~OsBIMK1~OsMPK3, A redox-sensitive cysteine residue regulates the kinase activities of OsMPK3 and OsMPK6 in vitro., Here, immunoprecipitated OsMPK3 and OsMPK6 were initially activated in 15min, and this activation transiently increased in rice seedlings under H2O2 stress
- OsMKK1, OsMPK6~OsMPK4, The mitogen-activated protein kinase cascade MKK1-MPK4 mediates salt signaling in rice., Yeast two-hybrid and in vitro and in vivo kinase assays revealed that OsMKK1 targeted OsMPK4
- OsMKK1, OsMPK6~OsMPK4, The mitogen-activated protein kinase cascade MKK1-MPK4 mediates salt signaling in rice., OsMPK4 activity was increased by salt, which was impaired in osmkk1 plants
- OsMKK1, OsMPK6~OsMPK4, The mitogen-activated protein kinase cascade MKK1-MPK4 mediates salt signaling in rice., In contrast, overexpression of OsMKK1 increased OsMPK4 activity in protoplasts
- OsMKK1, OsMPK6~OsMPK4, The mitogen-activated protein kinase cascade MKK1-MPK4 mediates salt signaling in rice., Taken together, the data suggest that OsMKK1 and OsMPK4 constitute a signaling pathway that regulates salt stress tolerance in rice
- OsMPK6~OsMPK4, OsMSRMK2~OsMAP1~OsMPK5~OsMAPK2~OsMAPK5~OsBIMK1~OsMPK3, A redox-sensitive cysteine residue regulates the kinase activities of OsMPK3 and OsMPK6 in vitro., Two subgroup A rice mitogen-activated protein kinases (MAPKs), OsMPK3 and OsMPK6, have been implicated in multiple stress responses
- OsMPK6~OsMPK4, OsMSRMK2~OsMAP1~OsMPK5~OsMAPK2~OsMAPK5~OsBIMK1~OsMPK3, A redox-sensitive cysteine residue regulates the kinase activities of OsMPK3 and OsMPK6 in vitro., Among the six conserved cysteine residues, only the fourth cysteine residues in the kinase domain VII, Cys(179) and Cys(210), were required for the in vitro kinase activities of OsMPK3 and OsMPK6, respectively
- OsMPK6~OsMPK4, OsWRKY53, The rice transcription factor WRKY53 suppresses herbivore-induced defenses by acting as a negative feedback modulator of map kinase activity, The transcript levels of OsWRKY53 are independent of endogenous jasmonic acid (JA), but positively regulated by the mitogen-activated protein kinases (MPKs), OsMPK3/OsMPK6
- OsMPK6~OsMPK4, OsWRKY53, The rice transcription factor WRKY53 suppresses herbivore-induced defenses by acting as a negative feedback modulator of map kinase activity, OsWRKY53 physically interacts with OsMPK3/OsMPK6 and suppresses their activity in vitro
- OsMPK6~OsMPK4, OsWRKY45~WRKY45, Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6., An ABA treatment dephosphorylated/inactivated OsMPK6 via protein tyrosine phosphatases, OsPTP1/2, leading to the impaired activation of WRKY45 and a reduction in Magnaporthe oryzae resistance, even after BTH treatment
- OsMPK6~OsMPK4, OsPTP1, Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6, An ABA treatment dephosphorylated/inactivated OsMPK6 via protein tyrosine phosphatases, OsPTP1/2, leading to the impaired activation of WRKY45 and a reduction in Magnaporthe oryzae resistance, even after BTH treatment
- OsMPK6~OsMPK4, OsPTP2, Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6, An ABA treatment dephosphorylated/inactivated OsMPK6 via protein tyrosine phosphatases, OsPTP1/2, leading to the impaired activation of WRKY45 and a reduction in Magnaporthe oryzae resistance, even after BTH treatment
- OsMPK6~OsMPK4, OsWRKY45~WRKY45, Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6, An ABA treatment dephosphorylated/inactivated OsMPK6 via protein tyrosine phosphatases, OsPTP1/2, leading to the impaired activation of WRKY45 and a reduction in Magnaporthe oryzae resistance, even after BTH treatment
- OsMPK6~OsMPK4, OsWRKY45~WRKY45, Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6, Phosphorylation of WRKY45, the central transcription factor in salicylic-acid (SA)-signalling-dependent pathogen defence in rice, via the OsMKK10-2-OsMPK6 cascade, was required to fully activate WRKY45
- OsMKK10-2~MPKK10.2, OsMPK6~OsMPK4, Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6, Phosphorylation of WRKY45, the central transcription factor in salicylic-acid (SA)-signalling-dependent pathogen defence in rice, via the OsMKK10-2-OsMPK6 cascade, was required to fully activate WRKY45
- OsMPK6~OsMPK4, OsWRKY45~WRKY45, WRKY45 phosphorylation at threonine 266 acts negatively on WRKY45-dependent blast resistance in rice., WRKY45 is a central regulator of disease resistance mediated by salicylic acid signaling in rice and its activation involves phosphorylation by OsMPK6
- OsMPK6~OsMPK4, OsWRKY45~WRKY45, WRKY45 phosphorylation at threonine 266 acts negatively on WRKY45-dependent blast resistance in rice., OsMPK6 phosphorylates WRKY45 at Thr266, Ser294, and Ser299 in vitro
Prev Next