RAD51C

2022-11-15 | Categories genes  | Tags meiosis  fertility  reproductive  anther  mitosis  pollen  meiotic  vegetative  sterility 

• Information
  • Symbol: RAD51C
  • MSU: LOC_Os01g39630
  • RAPdb: Os01g0578000
• PSP score
  • LOC_Os01g39630.2: 0.1457
  • LOC_Os01g39630.1: 0.0766
• PLAAC score
  • LOC_Os01g39630.2: 0
  • LOC_Os01g39630.1: 0
• pLDDT score
  • 85.87
• Protein Structure from AlphaFold and UniProt
  • 
• Publication
  • The rice RAD51C gene is required for the meiosis of both female and male gametocytes and the DNA repair of somatic cells, 2012, J Exp Bot.
• Genbank accession number
  • AK060971
• Key message
  • These results suggest that RAD51C is essential for reproductive development by regulating meiosis as well as for DNA damage repair in somatic cells
  • The rice RAD51C gene is required for the meiosis of both female and male gametocytes and the DNA repair of somatic cells
  • Transferring RAD51C to the RAD51C-KO line restored fertility
  • The RAD51C-KO line showed no obvious difference from wild-type plants in mitosis in the anther wall cells, which was consistent with the observation that the RAD51C-KO line did not have obviously abnormal morphology during vegetative development
  • Cytological analyses showed that the sterility of RAD51C-KO plants was associated with abnormal early meiotic processes in both megasporocytes and pollen mother cells (PMCs)
  • Knockout (KO) of RAD51C resulted in both female and male sterility in rice
• Connection
  • RAD51C, XRCC3, XRCC3 is essential for proper double-strand break repair and homologous recombination in rice meiosis., Moreover, abnormal chromosome localization of RAD51C, DMC1, ZEP1, ZIP4, and MER3 was observed in xrcc3
  • MOF, RAD51C, MEIOTIC F-BOX Is Essential for Male Meiotic DNA Double Strand Break Repair in Rice., The recruitment of Completion of meiosis I (COM1) and Radiation sensitive51C (RAD51C) to DSBs is severely compromised in mutant meiocytes, indicating that MOF is crucial for DSB end-processing and repair

Prev     Next