XA10

2022-11-15 | Categories genes  | Tags bacterial blight  cell death  homeostasis  blight  disease  disease resistance  resistance  R protein 

• Information
  • Symbol: XA10
  • MSU: LOC_Os11g37620
  • RAPdb: Os11g0586701
• PSP score
  • LOC_Os11g37620.1: 0.0039
• PLAAC score
  • LOC_Os11g37620.1: 0
• pLDDT score
  • NA
• Publication
  • The rice TAL effector-dependent resistance protein XA10 triggers cell death and calcium depletion in the endoplasmic reticulum, 2014, Plant Cell.
  • Genetic engineering of the Xa10 promoter for broad-spectrum and durable resistance to Xanthomonas oryzae pv. oryzae., 2015, Plant Biotechnol J.
  • Induction of Xa10-like genes in rice cultivar Nipponbare confers disease resistance to rice bacterial blight., 2017, Mol Plant Microbe Interact.
• Genbank accession number
  • JX025645
• Key message
  • Here, we report the cloning and characterization of Xa10, a transcription activator-like (TAL) effector-dependent R gene for resistance to bacterial blight in rice (Oryza sativa)
  • Expression of Xa10 induces programmed cell death in rice, Nicotiana benthamiana, and mammalian HeLa cells
  • XA10 variants that abolish programmed cell death and ER Ca(2+) depletion in N
  • We propose that XA10 is an inducible, intrinsic terminator protein that triggers programmed cell death by a conserved mechanism involving disruption of the ER and cellular Ca(2+) homeostasis
  • The rice TAL effector-dependent resistance protein XA10 triggers cell death and calcium depletion in the endoplasmic reticulum
  • The rice TAL effector-dependent disease resistance gene Xa10 confers narrow-spectrum race-specific resistance to Xanthomonas oryzae pv
  • Genetic engineering of the Xa10 promoter for broad-spectrum and durable resistance to Xanthomonas oryzae pv. oryzae.
  • To generate broad-spectrum and durable resistance to Xoo, we developed a modified Xa10 gene, designated as Xa10(E5)
  • The rice disease resistance (R) genes Xa10 confers race-specific disease resistance to X
  • Xa10 encodes an executor R protein that triggers hypersensitive response and activates disease resistance
  • Transgenic rice plants containing Xa10-Ni and Xa23-Ni under the Xa10 promoter provided specific disease resistance to X
  • The 19-amino acid residues at the N-terminal regions of XA10 or XA10-Ni are dispensable for their function in inducing cell death in N
• Connection
  • XA10, Xa10-Ni, Induction of Xa10-like genes in rice cultivar Nipponbare confers disease resistance to rice bacterial blight., Transgenic rice plants containing Xa10-Ni and Xa23-Ni under the Xa10 promoter provided specific disease resistance to X
  • XA10, Xa10-Ni, Induction of Xa10-like genes in rice cultivar Nipponbare confers disease resistance to rice bacterial blight., The 19-amino acid residues at the N-terminal regions of XA10 or XA10-Ni are dispensable for their function in inducing cell death in N
  • XA10, Xa10-Ni, Induction of Xa10-like genes in rice cultivar Nipponbare confers disease resistance to rice bacterial blight., benthamiana and the C-terminal regions of XA10, XA10-Ni and XA23-Ni are interchangeable among each other without affecting their function
  • XA10, Xa10-Ni, Induction of Xa10-like genes in rice cultivar Nipponbare confers disease resistance to rice bacterial blight., Like XA10, both XA10-Ni and XA23-Ni locate to the endoplasmic reticulum (ER) membrane, show self-interaction and induce ER Ca2+ depletion in leaf cells of N

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