ZEP1

2022-11-15 | Categories genes  | Tags meiotic  drought  microspore  meiosis  ABA 

• Information
  • Symbol: ZEP1
  • MSU: LOC_Os04g37960
  • RAPdb: Os04g0452500
• PSP score
  • LOC_Os04g37960.1: 0.8259
• PLAAC score
  • LOC_Os04g37960.1: 0
• pLDDT score
  • 74.34
• Protein Structure from AlphaFold and UniProt
  • 
• Publication
  • OsAM1 is required for leptotene-zygotene transition in rice, 2011, Cell Res.
  • ZIP4 in homologous chromosome synapsis and crossover formation in rice meiosis, 2012, J Cell Sci.
  • OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis, 2011, Plant J.
  • The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, 2012, Plant J.
  • The central element protein ZEP1 of the synaptonemal complex regulates the number of crossovers during meiosis in rice, 2010, Plant Cell.
  • Central region component1, a novel synaptonemal complex component, is essential for meiotic recombination initiation in rice, 2013, Plant Cell.
  • OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis, 2011, Plant Physiol.
  • OsSPO11-1 is essential for both homologous chromosome pairing and crossover formation in rice, 2010, Chromosoma.
  • The rice OsDIL gene plays a role in drought tolerance at vegetative and reproductive stages, 2013, Plant Mol Biol.
• Genbank accession number
  • GU479042
• Key message
  • In the absence of OsAM1, many other critical meiotic components, including PAIR2, ZEP1 and OsMER3, could not be correctly installed onto chromosomes
  • The expression levels of the drought-responsive genes RD22, SODA1, bZIP46 and POD, as well as the ABA synthetic gene ZEP1 were up-regulated in the OsDIL-overexpression lines but the ABA degradation gene ABAOX3 was down-regulated
  • In addition, ZEP1 is reloaded onto chromosomes in early microspores as the chromosome decondense, suggesting that ZEP1 might have other biological functions during this process
  • The central element protein ZEP1 of the synaptonemal complex regulates the number of crossovers during meiosis in rice
  • Finally, we found that the centromeric localization of OsSGO1 depends on OsAM1, not other meiotic proteins such as OsREC8, PAIR2, OsMER3, or ZEP1
  • Several key meiotic proteins, including ZEP1 and OsMER3, were not loaded normally onto chromosomes in Oscom1 mutants, whereas the localization of OsREC8, PAIR2 and PAIR3 seemed to be normal
  • Moreover, OsCOM1 was loaded normally onto meiotic chromosomes in Osrec8, zep1 and Osmer3 mutants, but could not be properly loaded in Osam1, pair2 and OsSPO11-1(RNAi) plants
  • In contrast, in pair2, Osmer3 and zep1 mutants, OsAM1 could be loaded normally, suggesting that OsAM1 plays a fundamental role in building the proper chromosome structure at the beginning of meiosis
• Connection
  • OsDIL~OsLTP6, ZEP1, The rice OsDIL gene plays a role in drought tolerance at vegetative and reproductive stages, The expression levels of the drought-responsive genes RD22, SODA1, bZIP46 and POD, as well as the ABA synthetic gene ZEP1 were up-regulated in the OsDIL-overexpression lines but the ABA degradation gene ABAOX3 was down-regulated
  • OsAREB8~OsAREB1~OsbZIP46~OsABF2~ABL1, ZEP1, The rice OsDIL gene plays a role in drought tolerance at vegetative and reproductive stages, The expression levels of the drought-responsive genes RD22, SODA1, bZIP46 and POD, as well as the ABA synthetic gene ZEP1 were up-regulated in the OsDIL-overexpression lines but the ABA degradation gene ABAOX3 was down-regulated
  • OsAM1, ZEP1, OsAM1 is required for leptotene-zygotene transition in rice, In the absence of OsAM1, many other critical meiotic components, including PAIR2, ZEP1 and OsMER3, could not be correctly installed onto chromosomes
  • OsAM1, ZEP1, OsAM1 is required for leptotene-zygotene transition in rice, In contrast, in pair2, Osmer3 and zep1 mutants, OsAM1 could be loaded normally, suggesting that OsAM1 plays a fundamental role in building the proper chromosome structure at the beginning of meiosis
  • PAIR2, ZEP1, OsAM1 is required for leptotene-zygotene transition in rice, In the absence of OsAM1, many other critical meiotic components, including PAIR2, ZEP1 and OsMER3, could not be correctly installed onto chromosomes
  • PAIR2, ZEP1, OsAM1 is required for leptotene-zygotene transition in rice, In contrast, in pair2, Osmer3 and zep1 mutants, OsAM1 could be loaded normally, suggesting that OsAM1 plays a fundamental role in building the proper chromosome structure at the beginning of meiosis
  • MER3~RCK, ZEP1, OsAM1 is required for leptotene-zygotene transition in rice, In the absence of OsAM1, many other critical meiotic components, including PAIR2, ZEP1 and OsMER3, could not be correctly installed onto chromosomes
  • MER3~RCK, ZEP1, OsAM1 is required for leptotene-zygotene transition in rice, In contrast, in pair2, Osmer3 and zep1 mutants, OsAM1 could be loaded normally, suggesting that OsAM1 plays a fundamental role in building the proper chromosome structure at the beginning of meiosis
  • MER3~RCK, ZEP1, ZIP4 in homologous chromosome synapsis and crossover formation in rice meiosis, Here, we identify the rice ZIP4 homolog, a member of the ZMM gene group, and explore its relationship with two other characterized ZMM genes, MER3 and ZEP1
  • MER3~RCK, ZEP1, ZIP4 in homologous chromosome synapsis and crossover formation in rice meiosis, Although zep1 alone gives an increased chiasma number, both zip4 zep1 and mer3 zep1 show a much lower chiasma number than the zip4 or mer3 single mutants
  • MER3~RCK, ZEP1, ZIP4 in homologous chromosome synapsis and crossover formation in rice meiosis, These results imply that the normal functions of ZIP4 and MER3 are required for the regulation of COs by ZEP1
  • ZEP1, ZIP4~SPO22, ZIP4 in homologous chromosome synapsis and crossover formation in rice meiosis, Here, we identify the rice ZIP4 homolog, a member of the ZMM gene group, and explore its relationship with two other characterized ZMM genes, MER3 and ZEP1
  • ZEP1, ZIP4~SPO22, ZIP4 in homologous chromosome synapsis and crossover formation in rice meiosis, Although zep1 alone gives an increased chiasma number, both zip4 zep1 and mer3 zep1 show a much lower chiasma number than the zip4 or mer3 single mutants
  • ZEP1, ZIP4~SPO22, ZIP4 in homologous chromosome synapsis and crossover formation in rice meiosis, These results imply that the normal functions of ZIP4 and MER3 are required for the regulation of COs by ZEP1
  • OsAM1, ZEP1, OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis, Finally, we found that the centromeric localization of OsSGO1 depends on OsAM1, not other meiotic proteins such as OsREC8, PAIR2, OsMER3, or ZEP1
  • OsRad21-4~OsREC8, ZEP1, OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis, Finally, we found that the centromeric localization of OsSGO1 depends on OsAM1, not other meiotic proteins such as OsREC8, PAIR2, OsMER3, or ZEP1
  • PAIR2, ZEP1, OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis, Finally, we found that the centromeric localization of OsSGO1 depends on OsAM1, not other meiotic proteins such as OsREC8, PAIR2, OsMER3, or ZEP1
  • MER3~RCK, ZEP1, OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis, Finally, we found that the centromeric localization of OsSGO1 depends on OsAM1, not other meiotic proteins such as OsREC8, PAIR2, OsMER3, or ZEP1
  • OsSGO1, ZEP1, OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis, Finally, we found that the centromeric localization of OsSGO1 depends on OsAM1, not other meiotic proteins such as OsREC8, PAIR2, OsMER3, or ZEP1
  • OsRad21-4~OsREC8, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Several key meiotic proteins, including ZEP1 and OsMER3, were not loaded normally onto chromosomes in Oscom1 mutants, whereas the localization of OsREC8, PAIR2 and PAIR3 seemed to be normal
  • OsRad21-4~OsREC8, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Moreover, OsCOM1 was loaded normally onto meiotic chromosomes in Osrec8, zep1 and Osmer3 mutants, but could not be properly loaded in Osam1, pair2 and OsSPO11-1(RNAi) plants
  • OsSPO11-1~OsTOP6A1, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Moreover, OsCOM1 was loaded normally onto meiotic chromosomes in Osrec8, zep1 and Osmer3 mutants, but could not be properly loaded in Osam1, pair2 and OsSPO11-1(RNAi) plants
  • PAIR2, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Several key meiotic proteins, including ZEP1 and OsMER3, were not loaded normally onto chromosomes in Oscom1 mutants, whereas the localization of OsREC8, PAIR2 and PAIR3 seemed to be normal
  • PAIR2, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Moreover, OsCOM1 was loaded normally onto meiotic chromosomes in Osrec8, zep1 and Osmer3 mutants, but could not be properly loaded in Osam1, pair2 and OsSPO11-1(RNAi) plants
  • PAIR3, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Several key meiotic proteins, including ZEP1 and OsMER3, were not loaded normally onto chromosomes in Oscom1 mutants, whereas the localization of OsREC8, PAIR2 and PAIR3 seemed to be normal
  • OsCOM1, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Several key meiotic proteins, including ZEP1 and OsMER3, were not loaded normally onto chromosomes in Oscom1 mutants, whereas the localization of OsREC8, PAIR2 and PAIR3 seemed to be normal
  • OsCOM1, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Moreover, OsCOM1 was loaded normally onto meiotic chromosomes in Osrec8, zep1 and Osmer3 mutants, but could not be properly loaded in Osam1, pair2 and OsSPO11-1(RNAi) plants
  • MER3~RCK, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Several key meiotic proteins, including ZEP1 and OsMER3, were not loaded normally onto chromosomes in Oscom1 mutants, whereas the localization of OsREC8, PAIR2 and PAIR3 seemed to be normal
  • MER3~RCK, ZEP1, The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis, Moreover, OsCOM1 was loaded normally onto meiotic chromosomes in Osrec8, zep1 and Osmer3 mutants, but could not be properly loaded in Osam1, pair2 and OsSPO11-1(RNAi) plants
  • PAIR2, ZEP1, The central element protein ZEP1 of the synaptonemal complex regulates the number of crossovers during meiosis in rice, Although PAIR2 and MER3 were loaded normally in zep1, their dissociation was delayed severely compared with the wild type
  • MER3~RCK, ZEP1, The central element protein ZEP1 of the synaptonemal complex regulates the number of crossovers during meiosis in rice, Although PAIR2 and MER3 were loaded normally in zep1, their dissociation was delayed severely compared with the wild type
  • CRC1, ZEP1, Central region component1, a novel synaptonemal complex component, is essential for meiotic recombination initiation in rice, CRC1 colocalizes with ZEP1, the rice SC transverse filament protein, to the central region of SCs in a mutually dependent fashion
  • CRC1, ZEP1, Central region component1, a novel synaptonemal complex component, is essential for meiotic recombination initiation in rice, Consistent with this colocalization, CRC1 interacts with ZEP1 in yeast two-hybrid assays
  • OsRad21-4~OsREC8, ZEP1, OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis, Immunolocalization analyses revealed that the loading of PAIR2, PAIR3, OsMER3, and ZEP1 all depended on OsREC8
  • OsRad21-4~OsREC8, ZEP1, OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis, By contrast, the presence of the OsREC8 signal in pair2, pair3, Osmer3, and zep1 mutants indicated that the loading of OsREC8 did not rely on these four proteins
  • PAIR2, ZEP1, OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis, Immunolocalization analyses revealed that the loading of PAIR2, PAIR3, OsMER3, and ZEP1 all depended on OsREC8
  • PAIR2, ZEP1, OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis, By contrast, the presence of the OsREC8 signal in pair2, pair3, Osmer3, and zep1 mutants indicated that the loading of OsREC8 did not rely on these four proteins
  • MER3~RCK, ZEP1, OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis, Immunolocalization analyses revealed that the loading of PAIR2, PAIR3, OsMER3, and ZEP1 all depended on OsREC8
  • MER3~RCK, ZEP1, OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis, By contrast, the presence of the OsREC8 signal in pair2, pair3, Osmer3, and zep1 mutants indicated that the loading of OsREC8 did not rely on these four proteins
  • XRCC3, ZEP1, XRCC3 is essential for proper double-strand break repair and homologous recombination in rice meiosis., Moreover, abnormal chromosome localization of RAD51C, DMC1, ZEP1, ZIP4, and MER3 was observed in xrcc3
  • OsDMC1~DMC1B, ZEP1, OsDMC1 is not required for homologous pairing in rice meiosis., Moreover, OsDMC1 was not detected in pairing-defective mutants, such as pair2, pair3, Oscom1 and Osrad51c, while it was loaded onto meiotic chromosomes in zep1, Osmer3, Oszip4 and Oshei10

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